Probiotics vs N-Acetylcysteine
for mood
Stronger evidence: tie
Stronger effect: Probiotics
Safety: No notable interactions recorded for either.
For mood, the two are evidence-matched; the difference is in effect and safety.
Probiotics
grade C low certainty
small effects on mood/anxiety in some "psychobiotic" trials; strain-specific, heterogeneous
strain-dependent, adults
N-Acetylcysteine
grade C low certainty
preliminary evidence as an adjunct in some psychiatric conditions; not established as a standalone
1200–2400 mg/day, adults
sources: PMID:42221774 · PMID:10000012