Ginkgo vs Lion's Mane

for cognition

Stronger evidence: tie

Stronger effect: Ginkgo

Safety: Ginkgo carries a serious interaction; Lion's Mane has none recorded.

For cognition, the two are evidence-matched; the difference is in effect and safety.

grade C low certainty

no reliable benefit for preventing cognitive decline in large trials

grade C low certainty

early, small studies suggest a modest cognitive effect

~1 g/day, adults

sources: PMID:00000034 · PMID:00000010