Creatine vs Vitamin D

for mood

Stronger evidence: tie

Stronger effect: tie

Safety: Vitamin D carries a minor interaction; Creatine has none recorded.

For mood, the two are evidence-matched; the difference is in effect and safety.

grade C low certainty

emerging evidence as an adjunct for depressive symptoms; trials small

3–5 g/day, adults with depression

grade C low certainty

small mood benefit, mostly in people who are deficient

sources: PMID:42180567 · PMID:00000005