{"claimId":"clm_ec_b9-glucosamine-blood-sugar","version":1,"status":"current","verdict":"Glucosamine for blood sugar: Grade — at low certainty. Systematic review (11 studies, 6 RCTs): several studies found DECREASED insulin sensitivity or increased fasting glucose in people taking glucosamine, particularly those with baseline impaired glucose tolerance or insulin resistance. This is a caution signal, not a benefit — people with pre-diabetes or diabetes should be aware glucosamine may worsen glucose metabolism in some studies.","direction":"uncertain","magnitude":{"metric":"other","value":null,"unit":"","ci95":null,"humanReadable":"Systematic review (11 studies, 6 RCTs): several studies found DECREASED insulin sensitivity or increased fasting glucose in people taking glucosamine, particularly those with baseline impaired glucose tolerance or insulin resistance. This is a caution signal, not a benefit — people with pre-diabetes or diabetes should be aware glucosamine may worsen glucose metabolism in some studies.","baselineAbsoluteRisk":null},"certainty":"low","clinicalMeaning":"no_established_threshold","applicability":{"appliesTo":["adults, especially those with impaired glucose tolerance or insulin resistance"],"doesNotApply":["children"],"unknown":["pregnancy"]},"safetyQualifiers":[],"evidenceBundleId":"eb_ec_b9-glucosamine-blood-sugar","citations":[{"pmid":"21251987","design":"peer-reviewed"}],"reviewedBy":{"name":"Substrate editorial","credential":"Independent research collective"},"reviewedAt":"2026-07-16T16:40:53.301Z","dateModified":"2026-07-16T16:40:53.301Z","methodologyVersion":"v1","methodologyDoi":"https://doi.org/10.5281/zenodo.21364236","canonicalUrl":"https://evidencebased.info/interventions/glucosamine/blood-sugar","attribution":"Substrate (evidencebased.info), claim clm_ec_b9-glucosamine-blood-sugar v1, reviewed 2026-07-16","license":"CC-BY-4.0 — attribution with link required"}