{"claimId":"clm_ec_b9-ash-mood","version":1,"status":"current","verdict":"Ashwagandha for mood: Grade B at moderate certainty. Meta-analysis of 22 studies: ashwagandha supplementation significantly reduced stress, depression, and anxiety scores versus control, with a dose-response relationship observed for stress. One of the more consistent mental-health signals in the ashwagandha literature, though study quality and dosing vary.","direction":"benefit","magnitude":{"metric":"other","value":null,"unit":"","ci95":null,"humanReadable":"Meta-analysis of 22 studies: ashwagandha supplementation significantly reduced stress, depression, and anxiety scores versus control, with a dose-response relationship observed for stress. One of the more consistent mental-health signals in the ashwagandha literature, though study quality and dosing vary.","baselineAbsoluteRisk":null},"certainty":"moderate","clinicalMeaning":"small_but_potentially_useful","applicability":{"appliesTo":["adults"],"doesNotApply":["children"],"unknown":["pregnancy"]},"safetyQualifiers":["moderate_with_ssri"],"evidenceBundleId":"eb_ec_b9-ash-mood","citations":[{"pmid":"41644067","design":"peer-reviewed"}],"reviewedBy":{"name":"Substrate editorial","credential":"Independent research collective"},"reviewedAt":"2026-07-16T16:40:49.911Z","dateModified":"2026-07-16T16:40:49.911Z","methodologyVersion":"v1","methodologyDoi":"https://doi.org/10.5281/zenodo.21364236","canonicalUrl":"https://evidencebased.info/interventions/ashwagandha/mood","attribution":"Substrate (evidencebased.info), claim clm_ec_b9-ash-mood v1, reviewed 2026-07-16","license":"CC-BY-4.0 — attribution with link required"}