{"claimId":"clm_ec_b8-zinc-heart","version":1,"status":"current","verdict":"Zinc for heart health: Grade B at moderate certainty. GRADE-assessed meta-analysis of 75 studies: zinc supplementation significantly lowered several cardiometabolic risk markers — triglycerides, total cholesterol, fasting blood glucose, HbA1c, insulin resistance (HOMA-IR), and inflammatory markers (CRP, IL-6, TNF-alpha). A broad risk-factor signal across many biomarkers, not a demonstrated reduction in cardiovascular events.","direction":"benefit","magnitude":{"metric":"other","value":null,"unit":"","ci95":null,"humanReadable":"GRADE-assessed meta-analysis of 75 studies: zinc supplementation significantly lowered several cardiometabolic risk markers — triglycerides, total cholesterol, fasting blood glucose, HbA1c, insulin resistance (HOMA-IR), and inflammatory markers (CRP, IL-6, TNF-alpha). A broad risk-factor signal across many biomarkers, not a demonstrated reduction in cardiovascular events.","baselineAbsoluteRisk":null},"certainty":"moderate","clinicalMeaning":"small_but_potentially_useful","applicability":{"appliesTo":["adults with cardiometabolic risk factors"],"doesNotApply":["children"],"unknown":["pregnancy"]},"safetyQualifiers":[],"evidenceBundleId":"eb_ec_b8-zinc-heart","citations":[{"pmid":"37399684","design":"peer-reviewed"}],"reviewedBy":{"name":"Substrate editorial","credential":"Independent research collective"},"reviewedAt":"2026-07-16T16:40:43.312Z","dateModified":"2026-07-16T16:40:43.312Z","methodologyVersion":"v1","methodologyDoi":"https://doi.org/10.5281/zenodo.21364236","canonicalUrl":"https://evidencebased.info/interventions/zinc/heart-health","attribution":"Substrate (evidencebased.info), claim clm_ec_b8-zinc-heart v1, reviewed 2026-07-16","license":"CC-BY-4.0 proposed; reuse license pending governance ratification","dataSource":"live"}