{"claimId":"clm_ec_b8-creatine-heart","version":1,"status":"current","verdict":"Creatine for heart health: Grade — at low certainty. Meta-analysis of 8 RCTs: creatine supplementation showed no statistically significant effect on total cholesterol, LDL, HDL, or triglycerides versus control. Certainty of evidence was rated very low to low due to methodological limitations in the included trials.","direction":"null","magnitude":{"metric":"other","value":null,"unit":"","ci95":null,"humanReadable":"Meta-analysis of 8 RCTs: creatine supplementation showed no statistically significant effect on total cholesterol, LDL, HDL, or triglycerides versus control. Certainty of evidence was rated very low to low due to methodological limitations in the included trials.","baselineAbsoluteRisk":null},"certainty":"low","clinicalMeaning":"no_established_threshold","applicability":{"appliesTo":["adults"],"doesNotApply":["children"],"unknown":["pregnancy"]},"safetyQualifiers":[],"evidenceBundleId":"eb_ec_b8-creatine-heart","citations":[{"pmid":"42180567","design":"peer-reviewed"}],"reviewedBy":{"name":"Substrate editorial","credential":"Independent research collective"},"reviewedAt":"2026-07-16T16:40:35.991Z","dateModified":"2026-07-16T16:40:35.991Z","methodologyVersion":"v1","methodologyDoi":"https://doi.org/10.5281/zenodo.21364236","canonicalUrl":"https://evidencebased.info/interventions/creatine/heart-health","attribution":"Substrate (evidencebased.info), claim clm_ec_b8-creatine-heart v1, reviewed 2026-07-16","license":"CC-BY-4.0 — attribution with link required"}