{"claimId":"clm_ec_b8-creatine-heart","grade":null,"version":0,"status":"current","verdict":"Creatine for heart health: Grade — at low certainty. Meta-analysis of 8 RCTs: creatine supplementation showed no statistically significant effect on total cholesterol, LDL, HDL, or triglycerides versus control. Certainty of evidence was rated very low to low due to methodological limitations in the included trials.","direction":"null","magnitude":{"metric":"other","value":null,"unit":"","ci95":null,"humanReadable":"Meta-analysis of 8 RCTs: creatine supplementation showed no statistically significant effect on total cholesterol, LDL, HDL, or triglycerides versus control. Certainty of evidence was rated very low to low due to methodological limitations in the included trials.","baselineAbsoluteRisk":null},"certainty":"low","clinicalMeaning":"no_established_threshold","applicability":{"appliesTo":["adults"],"doesNotApply":[],"unknown":[]},"safetyQualifiers":[],"evidenceBundleId":"eb_ec_b8-creatine-heart","citations":[{"pmid":"42180567","design":"peer-reviewed"}],"reviewedBy":null,"reviewedAt":"2026-07-16T16:40:35.991Z","dateModified":"2026-07-16T16:40:35.991Z","methodologyVersion":"v1","methodologyDoi":"https://doi.org/10.5281/zenodo.21364236","canonicalUrl":"https://evidencebased.info/interventions/creatine/heart-health","attribution":"Substrate (evidencebased.info), claim clm_ec_b8-creatine-heart v0, reviewed 2026-07-16","license":"CC-BY-4.0 proposed; reuse license pending governance ratification","governanceMode":"legacy","governanceStatus":"legacy-unverified","dataSource":"live"}