{"claimId":"clm_ec_b6-probiotics-skin","version":1,"status":"current","verdict":"Probiotics for skin: Grade C at low certainty. Meta-analysis (21 studies): probiotic supplementation lowered the risk of eczema and atopic eczema in children versus control, with the effect strongest for probiotic combinations and for maternal intake during pregnancy. Benefit is specifically eczema PREVENTION in early childhood — no significant effect on asthma, rhinitis or other allergic outcomes, and this is not a treatment claim for adult skin.","direction":"benefit","magnitude":{"metric":"other","value":null,"unit":"","ci95":null,"humanReadable":"Meta-analysis (21 studies): probiotic supplementation lowered the risk of eczema and atopic eczema in children versus control, with the effect strongest for probiotic combinations and for maternal intake during pregnancy. Benefit is specifically eczema PREVENTION in early childhood — no significant effect on asthma, rhinitis or other allergic outcomes, and this is not a treatment claim for adult skin.","baselineAbsoluteRisk":null},"certainty":"low","clinicalMeaning":"small_but_potentially_useful","applicability":{"appliesTo":["infants and children (eczema prevention); maternal supplementation"],"doesNotApply":["children"],"unknown":["pregnancy"]},"safetyQualifiers":[],"evidenceBundleId":"eb_ec_b6-probiotics-skin","citations":[{"pmid":"34006167","design":"peer-reviewed"}],"reviewedBy":{"name":"Substrate editorial","credential":"Independent research collective"},"reviewedAt":"2026-07-16T16:23:31.962Z","dateModified":"2026-07-16T16:23:31.962Z","methodologyVersion":"v1","methodologyDoi":"https://doi.org/10.5281/zenodo.21364236","canonicalUrl":"https://evidencebased.info/interventions/probiotics/skin","attribution":"Substrate (evidencebased.info), claim clm_ec_b6-probiotics-skin v1, reviewed 2026-07-16","license":"CC-BY-4.0 — attribution with link required"}