{"claimId":"clm_ec_b5-mel-mood","version":1,"status":"current","verdict":"Melatonin for mood: Grade C at low certainty. Systematic review: melatonin has been studied as a treatment for mood disorders, with some signal in specific contexts (e.g. seasonal or circadian-related), but overall evidence for a mood benefit is limited and inconsistent.","direction":"benefit","magnitude":{"metric":"other","value":null,"unit":"","ci95":null,"humanReadable":"Systematic review: melatonin has been studied as a treatment for mood disorders, with some signal in specific contexts (e.g. seasonal or circadian-related), but overall evidence for a mood benefit is limited and inconsistent.","baselineAbsoluteRisk":null},"certainty":"low","clinicalMeaning":"small_but_potentially_useful","applicability":{"appliesTo":["adults with mood symptoms"],"doesNotApply":["children"],"unknown":["pregnancy"]},"safetyQualifiers":["uncertain_with_ssri"],"evidenceBundleId":"eb_ec_b5-mel-mood","citations":[{"pmid":"28612993","design":"peer-reviewed"}],"reviewedBy":{"name":"Substrate editorial","credential":"Independent research collective"},"reviewedAt":"2026-07-16T15:25:10.391Z","dateModified":"2026-07-16T15:25:10.391Z","methodologyVersion":"v1","methodologyDoi":"https://doi.org/10.5281/zenodo.21364236","canonicalUrl":"https://evidencebased.info/interventions/melatonin/mood","attribution":"Substrate (evidencebased.info), claim clm_ec_b5-mel-mood v1, reviewed 2026-07-16","license":"CC-BY-4.0 — attribution with link required"}