{"claimId":"clm_ec_b5-berberine-heart","version":1,"status":"current","verdict":"Berberine for heart health: Grade B at moderate certainty. Meta-analysis of RCTs: berberine improved several cardiovascular risk factors — lowering total and LDL cholesterol, triglycerides, and blood pressure — versus control. It is a risk-factor signal, not a demonstrated reduction in cardiovascular events.","direction":"benefit","magnitude":{"metric":"other","value":null,"unit":"","ci95":null,"humanReadable":"Meta-analysis of RCTs: berberine improved several cardiovascular risk factors — lowering total and LDL cholesterol, triglycerides, and blood pressure — versus control. It is a risk-factor signal, not a demonstrated reduction in cardiovascular events.","baselineAbsoluteRisk":null},"certainty":"moderate","clinicalMeaning":"small_but_potentially_useful","applicability":{"appliesTo":["adults with cardiovascular risk factors"],"doesNotApply":["children"],"unknown":["pregnancy"]},"safetyQualifiers":["moderate_with_metformin"],"evidenceBundleId":"eb_ec_b5-berberine-heart","citations":[{"pmid":"36313096","design":"peer-reviewed"}],"reviewedBy":{"name":"Substrate editorial","credential":"Independent research collective"},"reviewedAt":"2026-07-16T15:57:29.234Z","dateModified":"2026-07-16T15:57:29.234Z","methodologyVersion":"v1","methodologyDoi":"https://doi.org/10.5281/zenodo.21364236","canonicalUrl":"https://evidencebased.info/interventions/berberine/heart-health","attribution":"Substrate (evidencebased.info), claim clm_ec_b5-berberine-heart v1, reviewed 2026-07-16","license":"CC-BY-4.0 — attribution with link required"}