{"claimId":"clm_ec_b4-mel-migraine","version":1,"status":"current","verdict":"Melatonin for migraine frequency: Grade C at low certainty. Systematic review: melatonin showed promise for migraine prophylaxis, reducing attack frequency in several trials, with a tolerability profile comparable to or better than some standard preventives. The evidence base is small and heterogeneous.","direction":"benefit","magnitude":{"metric":"other","value":null,"unit":"","ci95":null,"humanReadable":"Systematic review: melatonin showed promise for migraine prophylaxis, reducing attack frequency in several trials, with a tolerability profile comparable to or better than some standard preventives. The evidence base is small and heterogeneous.","baselineAbsoluteRisk":null},"certainty":"low","clinicalMeaning":"small_but_potentially_useful","applicability":{"appliesTo":["adults with migraine, prophylaxis"],"doesNotApply":["children"],"unknown":["pregnancy"]},"safetyQualifiers":["uncertain_with_ssri"],"evidenceBundleId":"eb_ec_b4-mel-migraine","citations":[{"pmid":"30653130","design":"peer-reviewed"}],"reviewedBy":{"name":"Substrate editorial","credential":"Independent research collective"},"reviewedAt":"2026-07-16T15:19:26.568Z","dateModified":"2026-07-16T15:19:26.568Z","methodologyVersion":"v1","methodologyDoi":"https://doi.org/10.5281/zenodo.21364236","canonicalUrl":"https://evidencebased.info/interventions/melatonin/migraine","attribution":"Substrate (evidencebased.info), claim clm_ec_b4-mel-migraine v1, reviewed 2026-07-16","license":"CC-BY-4.0 — attribution with link required"}