{"claimId":"clm_ec_b4-coq10-migraine","version":1,"status":"current","verdict":"CoQ10 for migraine frequency: Grade B at moderate certainty. Meta-analysis of RCTs: CoQ10 supplementation reduced migraine attack frequency (and, in some trials, duration) versus placebo; effect on migraine severity was less consistent. Trials are relatively small, so certainty is moderate rather than high.","direction":"benefit","magnitude":{"metric":"other","value":null,"unit":"","ci95":null,"humanReadable":"Meta-analysis of RCTs: CoQ10 supplementation reduced migraine attack frequency (and, in some trials, duration) versus placebo; effect on migraine severity was less consistent. Trials are relatively small, so certainty is moderate rather than high.","baselineAbsoluteRisk":null},"certainty":"moderate","clinicalMeaning":"small_but_potentially_useful","applicability":{"appliesTo":["adults with episodic migraine, prophylaxis"],"doesNotApply":["children"],"unknown":["pregnancy"]},"safetyQualifiers":[],"evidenceBundleId":"eb_ec_b4-coq10-migraine","citations":[{"pmid":"33402403","design":"peer-reviewed"}],"reviewedBy":{"name":"Substrate editorial","credential":"Independent research collective"},"reviewedAt":"2026-07-16T15:18:54.262Z","dateModified":"2026-07-16T15:18:54.262Z","methodologyVersion":"v1","methodologyDoi":"https://doi.org/10.5281/zenodo.21364236","canonicalUrl":"https://evidencebased.info/interventions/coq10/migraine","attribution":"Substrate (evidencebased.info), claim clm_ec_b4-coq10-migraine v1, reviewed 2026-07-16","license":"CC-BY-4.0 — attribution with link required"}