{"claimId":"clm_ec_b12-creatine-inflammation","version":1,"status":"current","verdict":"Creatine for inflammation: Grade — at moderate certainty. Meta-analysis: creatine supplementation did not significantly reduce inflammatory biomarkers (CRP, IL-6) in humans, either acutely or chronically. Certainty of evidence was rated moderate. The authors note some benefit was observed specifically under conditions of intense physical stress, but the general anti-inflammatory claim is not supported.","direction":"null","magnitude":{"metric":"other","value":null,"unit":"","ci95":null,"humanReadable":"Meta-analysis: creatine supplementation did not significantly reduce inflammatory biomarkers (CRP, IL-6) in humans, either acutely or chronically. Certainty of evidence was rated moderate. The authors note some benefit was observed specifically under conditions of intense physical stress, but the general anti-inflammatory claim is not supported.","baselineAbsoluteRisk":null},"certainty":"moderate","clinicalMeaning":"no_established_threshold","applicability":{"appliesTo":["adults"],"doesNotApply":["children"],"unknown":["pregnancy"]},"safetyQualifiers":[],"evidenceBundleId":"eb_ec_b12-creatine-inflammation","citations":[{"pmid":"41798953","design":"peer-reviewed"}],"reviewedBy":{"name":"Substrate editorial","credential":"Independent research collective"},"reviewedAt":"2026-07-16T16:41:00.886Z","dateModified":"2026-07-16T16:41:00.886Z","methodologyVersion":"v1","methodologyDoi":"https://doi.org/10.5281/zenodo.21364236","canonicalUrl":"https://evidencebased.info/interventions/creatine/inflammation","attribution":"Substrate (evidencebased.info), claim clm_ec_b12-creatine-inflammation v1, reviewed 2026-07-16","license":"CC-BY-4.0 — attribution with link required"}