{"claimId":"clm_ec_b11-nmn-blood-sugar","version":1,"status":"current","verdict":"NMN for blood sugar: Grade — at low certainty. Review of 8 human RCTs (342 mainly non-diabetic middle-age/older adults, 14 days to 12 weeks, 250-2000 mg/day): NMN supplementation showed no significant benefit on fasting glucose, fasting insulin, HbA1c, insulin resistance (HOMA-IR), or lipid profile. Short-term NMN supplementation did not meaningfully improve glucose control in this population.","direction":"null","magnitude":{"metric":"other","value":null,"unit":"","ci95":null,"humanReadable":"Review of 8 human RCTs (342 mainly non-diabetic middle-age/older adults, 14 days to 12 weeks, 250-2000 mg/day): NMN supplementation showed no significant benefit on fasting glucose, fasting insulin, HbA1c, insulin resistance (HOMA-IR), or lipid profile. Short-term NMN supplementation did not meaningfully improve glucose control in this population.","baselineAbsoluteRisk":null},"certainty":"low","clinicalMeaning":"no_established_threshold","applicability":{"appliesTo":["middle-age/older adults, mainly non-diabetic"],"doesNotApply":["children"],"unknown":["pregnancy"]},"safetyQualifiers":[],"evidenceBundleId":"eb_ec_b11-nmn-blood-sugar","citations":[{"pmid":"39531138","design":"peer-reviewed"}],"reviewedBy":{"name":"Substrate editorial","credential":"Independent research collective"},"reviewedAt":"2026-07-16T16:40:58.584Z","dateModified":"2026-07-16T16:40:58.584Z","methodologyVersion":"v1","methodologyDoi":"https://doi.org/10.5281/zenodo.21364236","canonicalUrl":"https://evidencebased.info/interventions/nmn/blood-sugar","attribution":"Substrate (evidencebased.info), claim clm_ec_b11-nmn-blood-sugar v1, reviewed 2026-07-16","license":"CC-BY-4.0 — attribution with link required"}