{"claimId":"clm_ec_b10-mel-blood-sugar","version":1,"status":"current","verdict":"Melatonin for blood sugar: Grade C at low certainty. Meta-analysis of 12 RCTs: melatonin supplementation significantly reduced fasting glucose and improved insulin sensitivity (QUICKI index), but had no significant effect on insulin levels, HOMA-IR, or HbA1c. A partial biomarker signal on fasting glucose specifically, not comprehensive glycemic control.","direction":"benefit","magnitude":{"metric":"other","value":null,"unit":"","ci95":null,"humanReadable":"Meta-analysis of 12 RCTs: melatonin supplementation significantly reduced fasting glucose and improved insulin sensitivity (QUICKI index), but had no significant effect on insulin levels, HOMA-IR, or HbA1c. A partial biomarker signal on fasting glucose specifically, not comprehensive glycemic control.","baselineAbsoluteRisk":null},"certainty":"low","clinicalMeaning":"small_but_potentially_useful","applicability":{"appliesTo":["adults"],"doesNotApply":["children"],"unknown":["pregnancy"]},"safetyQualifiers":["uncertain_with_ssri"],"evidenceBundleId":"eb_ec_b10-mel-blood-sugar","citations":[{"pmid":"30396207","design":"peer-reviewed"}],"reviewedBy":{"name":"Substrate editorial","credential":"Independent research collective"},"reviewedAt":"2026-07-16T16:40:54.733Z","dateModified":"2026-07-16T16:40:54.733Z","methodologyVersion":"v1","methodologyDoi":"https://doi.org/10.5281/zenodo.21364236","canonicalUrl":"https://evidencebased.info/interventions/melatonin/blood-sugar","attribution":"Substrate (evidencebased.info), claim clm_ec_b10-mel-blood-sugar v1, reviewed 2026-07-16","license":"CC-BY-4.0 — attribution with link required"}