{"claimId":"clm_ec_b5-lions-mood","grade":"D","version":0,"status":"current","verdict":"Lion's Mane for mood: Grade D at very-low certainty. Review: Hericium erinaceus (lion's mane) has been reported to have mood and anxiety benefits in small studies, but the clinical evidence is very preliminary and not from large, confirmatory trials.","direction":"null","magnitude":{"metric":"other","value":null,"unit":"","ci95":null,"humanReadable":"Review: Hericium erinaceus (lion's mane) has been reported to have mood and anxiety benefits in small studies, but the clinical evidence is very preliminary and not from large, confirmatory trials.","baselineAbsoluteRisk":null},"certainty":"very_low","clinicalMeaning":"trivial","applicability":{"appliesTo":["adults with mood symptoms"],"doesNotApply":[],"unknown":[]},"safetyQualifiers":[],"evidenceBundleId":"eb_ec_b5-lions-mood","citations":[{"pmid":"40959699","design":"peer-reviewed"}],"reviewedBy":null,"reviewedAt":"2026-07-16T15:25:14.995Z","dateModified":"2026-07-16T15:25:14.995Z","methodologyVersion":"v1","methodologyDoi":"https://doi.org/10.5281/zenodo.21364236","canonicalUrl":"https://evidencebased.info/interventions/lions-mane/mood","attribution":"Substrate (evidencebased.info), claim clm_ec_b5-lions-mood v0, reviewed 2026-07-16","license":"CC-BY-4.0 proposed; reuse license pending governance ratification","governanceMode":"legacy","governanceStatus":"legacy-unverified","dataSource":"live"}